(S)-3-amino-2-methylpropionate transaminase

In enzymology, a (S)-3-amino-2-methylpropionate transaminase (EC 2.6.1.22) is an enzyme that catalyzes the chemical reaction

(S)-3-amino-2-methylpropanoate + 2-oxoglutarate 2-methyl-3-oxopropanoate + L-glutamate

Thus, the two substrates of this enzyme are (S)-3-amino-2-methylpropanoate and 2-oxoglutarate, whereas its two products are 2-methyl-3-oxopropanoate and L-glutamate.

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is (S)-3-amino-2-methylpropanoate:2-oxoglutarate aminotransferase. Other names in common use include L-3-aminoisobutyrate transaminase, beta-aminobutyric transaminase, L-3-aminoisobutyric aminotransferase, and beta-aminoisobutyrate-alpha-ketoglutarate transaminase. This enzyme participates in valine, leucine and isoleucine degradation.

References

IUBMB entry for 2.6.1.22
BRENDA references for 2.6.1.22 (Recommended.)
PubMed references for 2.6.1.22
PubMed Central references for 2.6.1.22
Google Scholar references for 2.6.1.22
Kakimoto Y, Kanazawa A, Taniguchi K, Sano I (1968). "Beta-aminoisobutyrate-alpha-ketoglutarate transaminase in relation to beta-aminoisobutyric aciduria". Biochim. Biophys. Acta. 156: 374–80. PMID 5641913.
Tamaki N, Sakata SF, Matsuda K (2000). "Purification, properties, and sequencing of aminoisobutyrate aminotransferases from rat liver". Methods. Enzymol. 324: 376–89. PMID 10989446.