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(S)-2-hydroxy-fatty-acid dehydrogenase

In enzymology, a (S)-2-hydroxy-fatty-acid dehydrogenase (EC 1.1.1.99) is an enzyme that catalyzes the chemical reaction

(S)-2-hydroxystearate + NAD⁺ 2-oxostearate + NADH + H⁺

Thus, the two substrates of this enzyme are (S)-2-hydroxystearate and NAD⁺, whereas its 3 products are 2-oxostearate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-2-hydroxystearate:NAD+ oxidoreductase. Other names in common use include dehydrogenase, L-2-hydroxy fatty acid, L-2-hydroxy fatty acid dehydrogenase, and 2-hydroxy fatty acid oxidase.

References

• IUBMB entry for 1.1.1.99
• BRENDA references for 1.1.1.99 (Recommended.)
• PubMed references for 1.1.1.99
• PubMed Central references for 1.1.1.99
• Google Scholar references for 1.1.1.99
• Huang WY, Tang J (1970). "Carboxyl-terminal sequence of human gastricsin and pepsin". J. Biol. Chem. 245: 2189–93. PMID 4909888. 

External links

The CAS registry number for this enzyme class is 37250-33-2.

• IUBMB entry for 1.1.1.99

• KEGG entry for 1.1.1.99

• BRENDA entry for 1.1.1.99

• NiceZyme view of 1.1.1.99

• EC2PDB: PDB structures for 1.1.1.99

• PRIAM entry for 1.1.1.99

• PUMA2 entry for 1.1.1.99

• IntEnz: Integrated Enzyme entry for 1.1.1.99

• MetaCyc entry for 1.1.1.99

• Atomic-resolution structures of enzymes belonging to this class

Gene Ontology (GO) codes

• EGO entry for GO code 0047050: (S)-2-hydroxy-fatty-acid dehydrogenase

• AMIGO entry for GO code 0047050: (S)-2-hydroxy-fatty-acid dehydrogenase