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(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase

In enzymology, a (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase (EC 2.1.1.115) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline S-adenosyl-L-homocysteine + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline

Thus, the two substrates of this enzyme are S-adenosyl methionine and (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline, whereas its two products are S-adenosylhomocysteine and N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase. This enzyme is also called norreticuline N-methyltransferase. This enzyme participates in alkaloid biosynthesis i.

References

• IUBMB entry for 2.1.1.115
• BRENDA references for 2.1.1.115 (Recommended.)
• PubMed references for 2.1.1.115
• PubMed Central references for 2.1.1.115
• Google Scholar references for 2.1.1.115
• Frenzel T, Zenk MH (1990). "Purification and characterization of three isoforms of S-adenosyl-L-methionine: (R,S)-tetrahydrobenzyl-isoquinoline N-methyltransferase from Berberis koetineana cell cultures". Phytochemistry 29: 3491–3497. doi:10.1016/0031-9422(90)85263-F. 

External links

The CAS registry number for this enzyme class is 132084-82-3.

• IUBMB entry for 2.1.1.115

• KEGG entry for 2.1.1.115

• BRENDA entry for 2.1.1.115

• NiceZyme view of 2.1.1.115

• EC2PDB: PDB structures for 2.1.1.115

• PRIAM entry for 2.1.1.115

• PUMA2 entry for 2.1.1.115

• IntEnz: Integrated Enzyme entry for 2.1.1.115

• MetaCyc entry for 2.1.1.115

• Atomic-resolution structures of enzymes belonging to this class

Gene Ontology (GO) codes

• EGO entry for GO code 0030776: (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase

• AMIGO entry for GO code 0030776: (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase