(4S)-limonene synthase

In enzymology, a (4S)-limonene synthase (EC 4.2.3.16) is an enzyme that catalyzes the chemical reaction

geranyl diphosphate (-)-(4S)-limonene + diphosphate

Hence, this enzyme has one substrate, geranyl diphosphate, and two products, (-)-(4S)-limonene and diphosphate.

This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The systematic name of this enzyme class is geranyl-diphosphate diphosphate-lyase [cyclizing, (-)-(4S)-limonene-forming]. Other names in common use include (-)-(4S)-limonene synthase, 4S-(-)-limonene synthase, geranyldiphosphate diphosphate lyase (limonene forming), geranyldiphosphate diphosphate lyase [cyclizing,, and (4S)-limonene-forming]. This enzyme participates in monoterpenoid biosynthesis.

References

IUBMB entry for 4.2.3.16
BRENDA references for 4.2.3.16 (Recommended.)
PubMed references for 4.2.3.16
PubMed Central references for 4.2.3.16
Google Scholar references for 4.2.3.16
Bohlmann J, Steele CL, Croteau R (1997). "Monoterpene synthases from grand fir (Abies grandis). cDNA isolation, characterization, and functional expression of myrcene synthase, (-)-(4S)-limonene synthase, and (-)-(1S,5S)-pinene synthase". J. Biol. Chem. 272: 21784–92. doi:10.1074/jbc.272.35.21784. PMID 9268308.
Colby SM, Alonso WR, Katahira EJ, McGarvey DJ, Croteau R (1993). "4S-limonene synthase from the oil glands of spearmint (Mentha spicata). cDNA isolation, characterization, and bacterial expression of the catalytically active monoterpene cyclase". J. Biol. Chem. 268: 23016–24. PMID 8226816.
Yuba A, Yazaki K, Tabata M, Honda G, Croteau R (1996). "cDNA cloning, characterization, and functional expression of 4S-(-)-limonene synthase from Perilla frutescens". Arch. Biochem. Biophys. 332: 280–7. doi:10.1006/abbi.1996.0343. PMID 8806736.