(3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring))

In enzymology, a [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] (EC 2.7.11.4) is an enzyme that catalyzes the chemical reaction

ATP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] ADP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] phosphate

Thus, the two substrates of this enzyme are ATP and [[[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)]]], whereas its 3 products are ADP, [[[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)]]], and phosphate.

This enzyme belongs to the family of transferases, specifically those transferring a phosphate group to the sidechain oxygen atom of serine or threonine residues in proteins (protein-serine/threonine kinases). The systematic name of this enzyme class is ATP:[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] phosphotransferase. Other names in common use include kinase, BCK, BCKD kinase, BCODH kinase, branched-chain alpha-ketoacid dehydrogenase kinase, branched-chain 2-oxo acid dehydrogenase kinase, branched-chain keto acid dehydrogenase kinase, branched-chain oxo acid dehydrogenase kinase (phosphorylating), and STK2.

References

IUBMB entry for 2.7.11.4
BRENDA references for 2.7.11.4 (Recommended.)
PubMed references for 2.7.11.4
PubMed Central references for 2.7.11.4
Google Scholar references for 2.7.11.4
Paxton R, Harris RA (1982). "Isolation of rabbit liver branched chain alpha-ketoacid dehydrogenase and regulation by phosphorylation". J. Biol. Chem. 257: 14433–9. PMID 7142221.
Wynn RM, Chuang JL, Cote CD, Chuang DT (2000). "Tetrameric assembly and conservation in the ATP-binding domain of rat branched-chain alpha-ketoacid dehydrogenase kinase". J. Biol. Chem. 275: 30512–9. doi:10.1074/jbc.M005075200. PMID 10903321.
Chuang JL, Wynn RM, Chuang DT (2002). "The C-terminal hinge region of lipoic acid-bearing domain of E2b is essential for domain interaction with branched-chain alpha-keto acid dehydrogenase kinase". J. Biol. Chem. 277: 36905–8. doi:10.1074/jbc.C200430200. PMID 12189132.
Popov KM, Hawes JW, Harris RA (1997). "Mitochondrial alpha-ketoacid dehydrogenase kinases: a new family of protein kinases". Adv. Second. Messenger. Phosphoprotein. Res. 31: 105–11. PMID 9344245.