(+)-delta-cadinene synthase

In enzymology, a (+)-delta-cadinene synthase (EC 4.2.3.13) is an enzyme that catalyzes the chemical reaction

2-trans,6-trans-farnesyl diphosphate (+)-delta-cadinene + diphosphate

Hence, this enzyme has one substrate, 2-trans,6-trans-farnesyl diphosphate, and two products, (+)-delta-cadinene and diphosphate.

This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The systematic name of this enzyme class is 2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, (+)-delta-cadinene-forming). This enzyme participates in terpenoid biosynthesis. It employs one cofactor, magnesium.

References

IUBMB entry for 4.2.3.13
BRENDA references for 4.2.3.13 (Recommended.)
PubMed references for 4.2.3.13
PubMed Central references for 4.2.3.13
Google Scholar references for 4.2.3.13
Chen XY, Chen Y, Heinstein P, Davisson VJ (1995). "Cloning, expression, and characterization of (+)-delta-cadinene synthase: a catalyst for cotton phytoalexin biosynthesis". Arch. Biochem. Biophys. 324: 255–66. doi:10.1006/abbi.1995.0038. PMID 8554317.
Davis EM, Tsuji J, Davis GD, Pierce ML, Essenberg M (1996). "Purification of (+)-delta-cadinene synthase, a sesquiterpene cyclase from bacteria-inoculated cotton foliar tissue". Phytochemistry. 41: 1047–55. doi:10.1016/0031-9422(95)00771-7. PMID 8728715.
Davis GD, Essenberg M (1995). "(+)-delta-Cadinene is a product of sesquiterpene cyclase activity in cotton". Phytochemistry 39: 553–567. doi:10.1016/0031-9422(95)00067-H.